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Image Search Results
Journal: Experimental & Molecular Medicine
Article Title: Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1
doi: 10.1038/s12276-019-0360-x
Figure Lengend Snippet: a Expression of mRNA encoding Hsp90 gene family members obtained from TCGA RNAseq data. Expression of mRNA encoding HSP90AA1, HSP90AB1 (Hsp90α/β), HSP90B1 (Grp94), and TRAP1 (TRAP1) in cancer and normal tissues from 52 patients with prostate cancer; ** p < 0.005, **** p < 0.0001. b Correlation between HSP90AA1 and TRAP1 (left), HSP90AB1 and TRAP1 (middle), and HSP90B1 and TRAP1 (right) expression in the TCGA RNAseq database. c Expression of Hsp90 paralogs in human prostate cancer specimens. The boundary between the normal (N) and tumor (T) regions is indicated. Tumor specimens were analyzed by immunofluorescence staining with anti-TRAP1, anti-Hsp90, and anti-Grp94 antibodies, and protein expression in single cells was analyzed by confocal microscopy. Scale bar, 1 mm. d Expression of TRAP1 vs. Hsp90 (left) and TRAP1 vs. Grp94 (right). Tumor specimens were analyzed as in c . Data from 87 cells are presented in scatter plots. Pearson correlation coefficient ( r ) and p values are indicated.
Article Snippet: The
Techniques: Expressing, Immunofluorescence, Staining, Confocal Microscopy